Journal article
Longitudinal Structural Brain Changes in Bipolar Disorder: A Multicenter Neuroimaging Study of 1232 Individuals by the ENIGMA Bipolar Disorder Working Group
C Abé, CRK Ching, B Liberg, AV Lebedev, I Agartz, TN Akudjedu, M Alda, D Alnæs, S Alonso-Lana, F Benedetti, M Berk, E Bøen, CDM Bonnin, F Breuer, K Brosch, RM Brouwer, EJ Canales-Rodríguez, DM Cannon, Y Chye, A Dahl Show all
Biological Psychiatry | Published : 2022
Abstract
Background: Bipolar disorder (BD) is associated with cortical and subcortical structural brain abnormalities. It is unclear whether such alterations progressively change over time, and how this is related to the number of mood episodes. To address this question, we analyzed a large and diverse international sample with longitudinal magnetic resonance imaging (MRI) and clinical data to examine structural brain changes over time in BD. Methods: Longitudinal structural MRI and clinical data from the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) BD Working Group, including 307 patients with BD and 925 healthy control subjects, were collected from 14 sites worldwide. Male and fe..
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Awarded by Angelini Pharma
Funding Acknowledgements
The St. Goran study was supported by grants from the Swedish Research Council (Grant No. 2018-02653 [to ML] ) , the Swedish Foundation for Stra-tegic Research (Grant No. KF10-0039 [to ML] ) , the Swedish Brain Founda-tion (Grant No. FO2020-0261 [to ML] ) , and the Swedish Government under the LUA/ALF agreement (Grant No. ALF 20170019 [to ML] ) . This study was funded by the South-Eastern Norway Regional Health Authority (to TE) and a research grant from Mrs. Throne-Holst (to TE) . The National University of Ireland Galway study was supported by grant funding from the Health Research Board (Grant No. HRA_POR/2011/100) . FOR2107 was supported by the German Research Foundation (Deutsche Forschungsgemeinschaft) (Grant Nos. KI 588/14-1, KI 588/14-2, KR 3822/5-1, KR 3822/7-2, and NE 2254/1-2) . This study was supported by Grants of Deutsche For-schungsgemeinschaft (Grant Nos. NE2254/2-1, NE2254/3-1, and NE2254/4-1 [to IN] ) . This study was supported by research grants from the National Healthcare Group, Singapore (Grant Nos. SIG/05004 and SIG/05028 [to KS] ) , and the Singapore Bioimaging Consortium (Grant No. RP C009/2006 [to KS] ) . This study is supported by the European Research Council under the European Union's Horizon 2020 Research and Innovation program (Grant No. 802998 [to LTW] ) , the Research Council of Norway (Grant No. 300767 [to LTW] ) , and the South-Eastern Norway Regional Health Authority (Grant No. 2019101 [to LTW] ) . The University of New South Wales "Kids and Sibs" Study was supported by the Australian National Medical and Health Research Council (Program Grant No. 1037196 and Investigator Grant No. 1177991 [to PBM] and Project Grant No. 1066177 [to JMF] ) , the Lansdowne Foundation, Good Talk and the Keith Pettigrew Family Bequest (to PM) . This study was supported by the Janette Mary O'Neil Research Fellowship (to JMF) . This study was supported by grants from the DeutscheForschungsgemeinschaft (German Research Council) (Grant No. INST 2105/57-1 [to WH] ) . CRKC was supported by NIA (Grant No. T32AG058507; National Institutes of Health (Grant No. U54EB020403) from the Big Data to Knowledge Program; and has received partial research support from Bio-gen, Inc. for work unrelated to the topic of this manuscript. This study was supported by Deutsche Forschungsgemeinschaft (Grant Nos. NE 2254/2-1, NE2254/3-1, and NE2254/4-1 [to IN] ) . This study was supported by the Spanish Ministry of Science, Innovation and Universities/Economy and Competitiveness/Instituto de Salud Carlos III (Grant Nos. PI15/00283 and CPII19/00009 [to EV, JR, JMG, and CdMB] ) , cofinanced by European Regional Development Fund Funds from the European Commission (A Way of Making Europe) (to EV, JR, JMG, and CdMB) , Centro de Investigacion Biomedica en Red de Salud Mental (to EV, JR, JMG, and CdMB) , and the Departament de Salut de la Generalitat de Catalunya, CERCA Programme/Generalitat de Catalunya (Grant Nos. 2017SGR1365, SLT002/16/00331, and SLT006/17/00357 [to EV, JR, JMG, CdMB] ) . This study was funded by the South-Eastern Norway Regional Health Authority (Grant Nos. 2019107 and 2020086 [to DA] ) . This study was supported by Norwegian Centre of Excellence grant (Grant No. 223273 [to BH] ) and KG Jebsen grant (Grant No. SKGJ-MED-008 [to BH] ) . This study was supported by funding from the Canadian Institutes of Health Research (Grant Nos. 103703, 106469, and 142255 [to TH] ) , Nova Scotia Health Research Foundation (to TH) , Dalhousie Clinical Research Scholarship (to TH) , Brain & Behavior Research Founda-tion (to TH) , and 2007 Young Investigator and 2015 Independent Investi-gator Awards (to TH) . This study was supported by the Research Council of Norway (Grant Nos. 223273 and 248828 [to OAA] ) , South-East Norway Health Authority (Grant No. 2019-108 [to OAA] ) , KG Jebsen Stiftelsen, University of Oslo Life:Science program, EU H2020 (Grant No. 847776 CoMorMent [to OAA] ) . This study was supported in part National Institutes of Health grants (Grant No. R01MH116147, R01MH121246, and R01MH111671 [to ENIGMA] ) .